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ER stress

Over the last few years we have developed an increasing interest in the role of endoplasmic reticulum (ER) stress in various conditions and especially in metabolic diseases. We are especially interested in understanding how variations in ER stress and the resulting unfolded protein response (UPR) interferes with the adaptation of individuals at different environments and the onset and progression of ER stress-associated pathologies. For our studies we use outbred deer mice (Peromyscus) as a model. These small mammals, although similar to mice possess unique sets of features that render them ideal for the study of stress biology in the context of genetically diverse populations.

Recent papers

Zhang Y, Huynh-Dam KT, Ding X, Sikirzhytski V, Lim CU, Broude E, Kiaris H. RASSF1 is identified by transcriptome coordination analysis as a target of ATF4. FEBS Open Bio. 2023 Feb 1. doi: 10.1002/2211-5463.13569. Epub ahead of print. PMID: 36723232.

Zhang Y, Lim C, Sikirzhytski V, Naderi A, Chatzistamou I and KIARIS H. The propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain. Disease Models & Mechanisms. (2021) 14 (10): dmm049113.

*Featured with First Person interview by Y. Zhang: Dis Model Mech (2021) 14 (10): dmm049278.

Soltanmohammadi E, Farmaki E, Zhang Y, Naderi A, Kaza V, Chatzistamou I, Kiaris H. Coordination in the unfolded protein response during aging in outbred deer mice. Experimental Gerontology. 2020 Dec 5;144:111191. doi: 10.1016/j.exger.2020.111191

Zhang Y, Chatzistamou I, Kiaris H. Coordination of the unfolded protein response during hepatic steatosis identifies CHOP as a specific regulator of hepatocyte ballooning. Cell Stress Chaperones. 2020 Jun 23. doi: 10.1007/s12192-020-01132-x

Yap KN, Yamada K, Zikeli S, Kiaris H, Hood WR. Evaluating endoplasmic reticulum stress and unfolded protein response through the lens of ecology and evolution. Biol Rev Camb Philos Soc. 2020 Nov 8. doi: 10.1111/brv.12667. PMID: 33164297. 

Havighorst A, Zhang Y, Farmaki E, Kaza V,  Chatzistamou I and.Kiaris H. Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease. Disease Models & Mechanisms  2019  : dmm.037242 doi: 10.1242/dmm.037242.

Featured with First Person interview by A.  Havighorst: Disease Models & Mechanisms 2019 12: dmm039255 doi: 10.1242/dmm.039255 Highlighted in “Lab Animal: Deer mice bring genetic diversity to metabolic research".


Zhang Y, Lucius M, Altomare D, Havighorst A, Farmaki E, Chatzistamou I, Shtutman M, and Kiaris H. Coordination analysis of gene expression points to the relative impact of different regulators during endoplasmic reticulum stress. DNA and Cell Biology. 2019 Jul 29. doi: 10.1089/dna.2019.4910 




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