Context specificity and carcinogenesis
Our laboratory is interested on how context specificity affects the kinetic profile, the morphology and the properties of malignant tumors. We are particularly intrigued by the fact that the same type of cancer cells can develop into different tumors depending on the constitution of microenvironment. Based on this notion we believe that appropriate manipulation of tumor stroma may serve as the basis for the development of novel cancer therapeutics and for the establishment of strategies that more accurately predict cancer risk and disease prognosis.
Kaza V, Farmaki E, Havighorst A, Crossland J, Chatzistamou I, Kiaris H. Growth of human breast cancers in Peromyscus. Dis Model Mech. 2018 Jan 17;11(1). pii: dmm031302. doi: 10.1242/dmm.031302.
Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB. CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res. 2018 Dec 1;78(23):6594-6606. doi: 10.1158/0008-5472.CAN-18-1583
Chatzistamou I, Farmaki E, Kaza V, Kiaris H. The Value of Outbred Rodent Models in Cancer Research. Trends in Cancer. 2018 Jul;4(7):468-471. doi: 10.1016/j.trecan.2018.05.00
Kiaris H, Chatzistamou I. Inhibition of tumor growth by agonists of growth hormone-releasing hormone. Proc Natl Acad Sci U S A. 2018 Nov 7. pii: 201817342. doi: 10.1073/pnas.181734211
Farmaki E, Kaza V, Chatzistamou I and Kiaris H. CCL8 promotes postpartum breast cancer by recruiting M2 macrophages. iScience. 2020 Jun 1;23(6):101217. doi: 10.1016/j.isci.2020.101217
Chavez B, Farmaki E, Zhang Y, Altomare D, Hao J, Soltnamohammadi E, Shtutman M, Chatzistamou I, & Kiaris H. A strategy for the Identification of Paracrine Regulators of Cancer Cell Migration. Clin Exp Pharmacol Physiol. 2020 Jun 25. doi: 10.1111/1440-1681.13366. Selected for the Journal's Cover