Transcriptional networks and genomics​

By focusing primarily on ER stress we are exploring how gene expression networks are modulated to attain homeostasis. Beyond ER stress, our approaches  are applied to other conditions and pathologies such as aging and cancer, as well as for the study of traits at the level of whole populations.

In parallel, we are actively engaged in genomic and transcriptomic studies in Peromyscus.  

Recent papers

Zhang Y, Lucius M, Altomare D, Havighorst A, Farmaki E, Chatzistamou I, Shtutman M, and Kiaris H. Coordination analysis of gene expression points to the relative impact of different regulators during endoplasmic reticulum stress. DNA and Cell Biology. 2019 Jul 29. doi: 10.1089/dna.2019.4910 

 

Zhang Y, Lucius M, Altomare D, Havighorst A, Farmaki E, Chatzistamou I, Shtutman M, and Kiaris H. Coordination analysis of gene expression points to the relative impact of different regulators during endoplasmic reticulum stress. DNA and Cell Biology. 2019 Jul 29. doi: 10.1089/dna.2019.4910 

Zhang Y, Chatzistamou I, Kiaris H. Identification of frailty-associated genes by coordination analysis of gene expression. Aging (Albany NY). 2020; . https://doi.org/10.18632/aging.102875

Zhang Y, Chatzistamou I, Kiaris H. Coordination of the unfolded protein response during hepatic steatosis identifies CHOP as a specific regulator of hepatocyte ballooning. Cell Stress Chaperones. 2020 Jun 23. doi: 10.1007/s12192-020-01132-x

 

Chavez B, Farmaki E, Zhang Y, Altomare D, Hao J, Soltnamohammadi E, Shtutman M, Chatzistamou I, & Kiaris H. A strategy for the Identification of Paracrine Regulators of Cancer Cell Migration. Clin Exp Pharmacol Physiol. 2020 Jun 25. doi: 10.1111/1440-1681.13366. Selected for the Journal's Cover 

Soltanmohammadi E, Farmaki E, Zhang Y, Naderi A, Kaza V, Chatzistamou I, Kiaris H. Coordination in the unfolded protein response during aging in outbred deer mice. Experimental Gerontology. 2020 Dec 5;144:111191. doi: 10.1016/j.exger.2020.111191

Balderrama-Gutierrez G, Milovic A, Cook VJ, Islam NM, Zhang Y, Kiaris H,  Belisle JT, Mortazavi A, Barbour AG. The infection-tolerant mammalian reservoir of Lyme disease and other zoonoses broadly counters the inflammatory effects of endotoxin. bioRxiv 2020.12.13.422519; doi: https://doi.org/10.1101/2020.12.13.422519

 

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