Kiaris Lab

Recent Publications by research topic


Kiaris H, Chatzistamou I, Trimis G, Frangou-Plemmenou M, Pafiti-Kondi A, Kalofoutis A. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res. 2005 Mar 1;65(5):1627-30. Discussed in Faculty of 1000 (

Lafkas D, Trimis G, Papavassiliou AG & Kiaris H. p53 mutations in stromal fibroblasts sensitize tumors against chemotherapy. International Journal of Cancer. 123(4):967-71. 2008.

Trimis G, Chatzistamou I, Politi K, Kiaris H, Papavassiliou AG Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors. Human Molecular Genetics. 17: 3596-3600, 2008.

Kiaris H, Trimis G and Papavassiliou AG. Regulation of tumor-stromal fibroblast interactions: Implications in anticancer therapy. Current Medicinal Chemistry. 15: 3062-3067, 2008.

Chatzistamou I, Dioufa N, Trimis G, Sklavounou A, Kittas C, Kiaris H, Papavassiliou AG. p21/waf1 and smooth-muscle actin α expression in stromal fibroblasts of oral cancers. Anal Cell Pathol (Amst). 2010;33(1):19-26.

Porter DC, Farmaki E, Altilia S, Schools GP,  et al. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804. 

Farmaki E, Chatzistamou I, Bourlis P, Santoukou E, Trimis G, Papavassiliou AG, Kiaris H. Selection of p53-Deficient Stromal Cells in the Tumor Microenvironment. Genes Cancer. 2012 Sep;3(9-10):592-8.

Soon P, Kiaris H. MicroRNAs in the tumour microenvironment: big role for small players. Endocr Relat Cancer. 2013 Aug 23;20(5): R257-67. doi: 10.1530/ERC-13-0119.

Farmaki E, Chatzistamou I, Kaza V, Kiaris H. A CCL8 gradient drives breast cancer cell disseminationOncogene. 2016 Dec 8;35(49):6309-6318. doi: 10.1038/onc.2016.161.

Farmaki E, Kaza V, Papavassiliou AG, Chatzistamou I, Kiaris H. Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Ccl3.. Cancer Lett. 2016 Dec 29;389:49-58

Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB. CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. Cancer Res. 2018 Sep 5. pii: canres.1583.2018. doi: 10.1158/0008-5472.CAN-18-1583.



Mkrtchian S, Baryshev M, Sargsyan E, Chatzistamou I, Volakaki AA, Chaviaras N, Pafiti A, Triantafyllou A, Kiaris H. ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts. Molecular Carcinogenesis. 47(11):886-92. 2008.

Mihailidou C, Papazian I, Papavassiliou AG, Kiaris H. CHOP-dependent regulation of p21/waf1 during ER stress. Cell Physiol Biochem. 2010;25(6):761-6.

Dioufa N, Kassi E, Papavassiliou AG, Kiaris H. Atypical induction of the unfolded protein response by mifepristone. Endocrine. 2010 Oct;38(2):167-73.

E. Farmaki, S. Mkrtchian, I. Papazian, A.G. Papavassiliou, H. Kiaris. ERp29 regulates response to doxorubicin by a PERK-mediated mechanism  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2011 Jun;1813(6):1165-71.

Dioufa N, Chatzistamou I, Farmaki E, Papavassiliou AG, Kiaris H. p53 antagonizes the unfolded protein response and inhibits ground glass hepatocyte development during endoplasmic reticulum stress. Exp Biol Med (Maywood). 2012 Oct 1;237(10):1173-80.

Mihailidou C, Papavassiliou AG, Kiaris H. A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (CHOP) linked to type 2 diabetes. Biochimie. 2013 Nov 14. doi:pii: S0300-9084(13)00399-4. 10.1016/j.biochi.2013.11.003.

Mihailidou C, Chatzistamou I, Papavassiliou A, Kiaris H. Improvement of chemotherapeutic drug efficacy by endoplasmic reticulum stress. Endocr Relat Cancer. 2015 Apr;22(2):229-38. Commented by S. Mkrtchian in Endocr Relat Canc

Mihailidou C, Chatzistamou I, Papavassiliou A, Kiaris H. Regulation of p21 during diabetes-associated stress of the endoplasmic reticulum. Endocr Relat Cancer. 2015 Apr;22(2):217-28.. Commented by S. Mkrtchian in Endocr Relat Canc . Featured in the cover of the November '15 issue of ERC

Mihailidou C, Katsoulas N, Panagiotou E, Farmaki E, Sklavounou A, Kiaris H, Chatzistamou I. Endoplasmic Reticulum stress is associated with the pathogenesis of Pemphigus Vulgaris. Exp Dermatol. 2016 Apr 6. doi: 10.1111/exd.13026. Featured in the cover of the September '16 issue of Experimental Dermatology

Adamopoulos C, Mihailidou C, Grivaki C, Papavassiliou KA, Kiaris H, Piperi C, Papavassiliou AG. Systemic effects of AGEs in ER stress induction in vivo. Glycoconj J. 2016 Aug;33(4):537-44. doi: 10.1007/s10719-016-9680-4

Mihailidou C, Panagiotou C, Kiaris H, Kassi E, Moutsatsou P. Crosstalk between C/EBP homologous protein (CHOP) and glucocorticoid receptor in lung cancer. Mol Cell Endocrinol. 2016 Aug 3;436:211-223. doi: 10.1016/j.mce.2016.08.001.

Mihailidou C, Chatzistamou I, Papavassiliou A, Kiaris H. Ciclopirox enhances pancreatic islet health by modulating the unfolded protein response in diabetes..  Pflügers Archiv - European Journal of Physiology. 2016 Nov;468(11-12):1957-1968.

Mihailidou C, Chatzistamou I, Papavassiliou A, Kiaris H. Modulation of pancreatic islets' function and survival during aging involves the differential regulation of endoplasmic reticulum stress by p21 and CHOP. Antioxid Redox Signal. 2017 Jan 16. doi: 10.1089/ars.2016.6671.

Mihailidou C, Papavassiliou AG, Kiaris H. Cell-autonomous cytotoxicity of type I interferon response via induction of endoplasmic reticulum stress. FASEB J. 2017 Aug 17. pii: fj.201700152R. doi: 10.1096/fj.201700152R 



Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S. Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol. 2004 Aug;165(2):695-705.

Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9262-7.

Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H, Fre S. Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol. 2013 Oct 14;203(1):47-56. doi: 10.1083/jcb.201307046

Havighorst A, Crossland J, Kiaris H. Peromyscus as a model of human disease. Semin Cell Dev Biol. 2016 Jun 29. pii: S1084-9521(16)30181-1. doi: 10.1016/j.semcdb.2016.06.020.

Chatzistamou I, Kiaris H. Modeling estrogen-receptor positive breast cancers in mice: is it the best we can do? Endocr Relat Cancer. 2016 Nov;23(11):C9-C12. 


Kiaris H. Editorial. Semin Cell Dev Biol. 2017 Jan;61:80-81. doi: 10.1016/j.semcdb.2016.12.005 

McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017 Jan 29. doi: 10.18632/oncotarget.14894.

McCluskey K, Boundy-Mills K, Dye G, Ehmke E, Gunnell G, Kiaris H, Richmond MP, Yoder AD, Zeigler DR, Zehr S, Grotewold E.The challenges faced by living stock collections in the USA. Elife. 2017 Mar 7;6. pii: e24611. doi: 10.7554/eLife.24611. 

Kaza V, Farmaki E, Havighorst A, Crossland J, Chatzistamou I, Kiaris H. Growth of human breast cancers in Peromyscus. Dis Model Mech. 2018 Jan 17;11(1). pii: dmm031302. doi: 10.1242/dmm.031302.

Chatzistamou I, Farmaki E, Kaza V, Kiaris H. The Value of Outbred Rodent Models in Cancer Research. Trends Cancer. 2018 Jul;4(7):468-471. doi: 10.1016/j.trecan.2018.05.00


For a list of research papers select here 




 Understanding Carcinogenesis

 WILEY-VCH, 2006










Genes, Polymorphisms and the Making of Societies: How Genetic Behavioral Traits Influence Human Cultures


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